The article considers a modern approach to the organization of career guidance and pre-university training with schoolchildren conducted at a medical university, which allows to promote professional self-determination of high school students at the stage of choosing a profession, the formation of personal and professional competencies that contribute to admission to medical and pharmaceutical education programs. The purpose of the work is to present the experience of implementing and implementing the model of career guidance work “School – Pre–University – University” on the example of the Pre-University of VSMU named after N.N. Burdenko for the formation of a career-oriented and high-quality contingent of students. Materials and methods: in the course of the research, an analytical method was used, including the analysis of experience and systematization of published scientific and methodological literature on the implementation of professional orientation of schoolchildren. The results of the study. Career guidance work at the higher medical school should be systematic and dynamic, taking into account the factors of personal growth, motivation of schoolchildren. Only in this case, career guidance will be comprehensive and will ensure a continuous process of professionalization at the pre-university stage of medical education. Conclusion: at the pre-university stage of education, an important role is assigned to Pre-universities. Professional orientation and training of students of the medical Pre-University provides the highest quality preparation of specialized training and the formation of the motivational potential of the student for the future profession.